Examining the Relationship between a Verbal Incidental Learning Measure from the WAIS-IV and Neuroimaging Biomarkers for Alzheimer's Pathology.
- Resource Type
- Academic Journal
- Authors
- Hammers DB; Center for Alzheimer's Care, Imaging, and Research, Department of Neurology, University of Utah , Salt Lake City, UT, USA.; Kucera A; University of Utah Health Care , Salt Lake City, UT, USA.; Spencer RJ; Mental Health Service, VA Ann Arbor Healthcare System , Ann Arbor, MI, USA.; Abildskov TJ; Traumatic Brain Injury and Concussion Center, Department of Neurology, University of Utah , Salt Lake City, UT, USA.; Archibald ZG; Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT, USA.; Hoffman JM; Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT, USA.; Wilde EA; Traumatic Brain Injury and Concussion Center, Department of Neurology, University of Utah , Salt Lake City, UT, USA.; George E. Wahlen Veterans Affairs Medical Center , Salt Lake City, UT, USA.
- Source
- Publisher: Routledge Country of Publication: England NLM ID: 8702038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6942 (Electronic) Linking ISSN: 15326942 NLM ISO Abbreviation: Dev Neuropsychol Subsets: MEDLINE
- Subject
- Language
- English
Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer's disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities performances were significantly associated with smaller hemispheric hippocampal volumes. IL measures were not significantly correlated with cerebral β-amyloid burden, though a trend was present and effect sizes were mild. These hippocampal volume results suggest that this IL task may be sensitive to AD pathology along the AD continuum.