Association of lipid peroxidation and interleukin-6 with carotid atherosclerosis in type 2 diabetes.
- Resource Type
- Academic Journal
- Authors
- Alharby H; Departments of Internal Medicine, Diabetes, Lipidology and Metabolism Unit.; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Taiz University, Taiz, Yemen.; Abdelati T; Departments of Internal Medicine, Diabetes, Lipidology and Metabolism Unit.; Rizk M; Clinical Pathology.; Youssef E; Departments of Internal Medicine, Diabetes, Lipidology and Metabolism Unit.; Moghazy K; Radiodiagnosis, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Gaber N; Departments of Internal Medicine, Diabetes, Lipidology and Metabolism Unit.; Yafei S; Departments of Internal Medicine, Diabetes, Lipidology and Metabolism Unit.; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Taiz University, Taiz, Yemen.
- Source
- Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101730894 Publication Model: eCollection Cited Medium: Internet ISSN: 2574-0954 (Electronic) Linking ISSN: 25740954 NLM ISO Abbreviation: Cardiovasc Endocrinol Metab Subsets: PubMed not MEDLINE
- Subject
- Language
- English
Enhanced lipid peroxidation and elevated interleukin-6 levels are common in type 2 diabetes mellitus patients. Atherosclerotic vascular complications greatly contribute to morbidity and mortality in diabetes. The aim of this study was to assess the relation of lipid peroxidation and interleukin-6 with carotid atherosclerosis in type 2 diabetes mellitus.
Methods: This cross-sectional study included 90 type 2 diabetes mellitus male patients with age ≥ 40 years and 30 healthy male subjects matched for age. All of them were subjected to measuring of 8-iso prostaglandin F2α as a marker of lipid peroxidation, interleukin-6 and carotid intima media thickness as a marker of carotid atherosclerosis.
Results: Both 8-iso prostaglandin F2α and interleukin-6 were found to have significant positive correlation with carotid intima media thickness ( P < 0.001) and both were found to be significant predictors of the presence of subclinical carotid atherosclerosis in multiple regression analysis.
Conclusion: Lipid peroxidation and interleukin-6 may play an important role in atherogenesis in type 2 diabetes mellitus and limiting their effects may reduce atherosclerotic vascular complications in type 2 diabetes mellitus.
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