Summary: The identification of two exosome components, Lrp1 and Rrp6, as novel mRNA export factors raises questions about the connection between DNA surveillance and repair, RNA surveillance, and RNA export. Using whole-genome mRNA stability profiling, we found that Lrp1 mediates large-scale mRNA degradation upon DNA-damaging UV irradiation as well as general mRNA degradation. Lrp1 requires Rrp6 for genomic localization to genes encoding its mRNA targets, and Rrp6 genomic localization in turn correlates with transcription. Further, Rrp6 and Lrp1 are both required for repair of UV-induced DNA damage. These results demonstrate coupling of genome-wide mRNA surveillance to mRNA export and reveal specificity of the RNAs surveillance machinery for distinct mRNA subpopulations.