Summary: Burnout affects greater than 50% of healthcare workers, with a higher prevalence found in newly licensed nurses, leading to a lower quality of patient care, with higher reported missed care, and medication errors. Burnout is a syndrome caused by organizational stress and is characterized as feelings of exhaustion, cynicism, and inefficacy. Research has explored burnout at the individual level, and little is known about how unit level variables affect or are related to burnout. The purpose of this study was to examine the effects of collective efficacy and nurses’ social network on burnout. A descriptive, cross-sectional survey method was used to assess 75 interprofessional providers on a unit at a 547-bed, level I trauma center in the Midwestern United States. Data were collected using surveys and analyzed using social network analysis and linear and multiple regression. Results from this study highlight the importance of the significant correlation between collective efficacy and burnout, and the potentially protective effect collective efficacy has on burnout. Results from the study also revealed a deeper understanding of burnout, specifically how social network analysis methods can be used to identify which individuals are at a greater risk of burnout, are identified as central to a unit’s social network, and potential ways to mitigate the development of burnout at a unit level.