Through synthesizing novel difluoro-monomer (1,6-N,N'-bis(4-fuorobenzamide) trimethylhexane (BFBT)) and adjusting the structure of bisphenol monomer (hydroquinone (HQ) or 4,4'-biphenol (BH)), two kinds of novel semi-aromatic polyamides (HQ-BBT and BH-BBT) containing ether bond and pendant methyl were synthesized in this work. The inherent viscosities of these obtained polymers were in the range of 0.921–1.151 dLg−1. The polyamides HQ-BBT and BH-BBT exhibited high glass transition temperatures (Tg) of 144–160 °C and weight loss temperature (T5%) of 401–406 °C. The resultant polyamides HQ-BBT and BH-BBT showed good melting flowability with complex viscosities of 1931–252 Pa s and 3829–376 Pa s, respectively, and they can be hot-pressed into thin films, which showed tensile strengths of 64.4–64.6 MPa and storage modulus over 1.28 GPa at about 150 °C, indicating their good thermal and mechanical properties. Interestingly, we found that the aggregation structures of these two kinds of polymers were quite different with the addition of different bisphenol. HQ-BBT with HQ as monomer was amorphous and can be dissolved in polar solvents such as NMP, DMF and so on, while BH-BBT with BH as monomer was found to be crystalline polymer with moderate melting point of 245 °C and much higher glass transition temperature of 160 °C. These moderate Tm and Tg were very beneficial for the melting processing of the high-performance polymers. [ABSTRACT FROM AUTHOR]