A practical and convenient Blanc-type chloromethylation catalyzed by zinc chloride under solvent-free conditions.
- Resource Type
- Article
- Authors
- Tang, Jian; Liu, Hongtao; He, Kailun; Zhang, Xingxian
- Source
- Synthetic Communications. 2019, Vol. 49 Issue 7, p925-932. 8p. 4 Diagrams, 1 Chart.
- Subject
- *ZINC chloride
*AROMATIC compounds
*SULFONIC acids
- Language
- ISSN
- 0039-7911
Chloromethylation of various aromatic hydrocarbons and substituted phenolic derivatives with dimethoxymethane and chlorosulfonic acid was carried out in the presence of 10 mol% of ZnCl2 in a mild and efficient manner under solvent-free conditions. In addition, 2,6-dimethyltyrosine was synthesized in high yield via this protocol. [ABSTRACT FROM AUTHOR]