Bulk samples of the GH3535 alloy weld metal have been characterized by transmission electron microscopy, X-ray diffraction and nanoindentation to determine their microstructural evolution and mechanical property changes after 8 MeV Ni 3+ ions irradiation. The irradiation experiments were carried out at room temperature and 600 °C, and the ion fluences correspond to a calculated peak damage dose of 0.5, 2 and 12 dpa, respectively. TEM results show the formation of solute clusters or dislocation loops with a number density of approximately 5–14 × 10 22 m −3 and sizes between 3 and 10 nm at room temperature due to irradiation induced defects and their evolution. Moreover, the peak shift with increasing ion dose observed in XRD diffraction patterns reveals the lattice distortion induced by ion irradiation. As far as the case of high temperature irradiation, several solute clusters with the same size were observed, whereas the number density was smaller than that of the former case. The calculated indentation values in irradiated samples were found to be much higher in comparison to the unirradiated one, indicating the dose dependent effect of irradiation on hardness. However, in the case of the ion irradiation at 600 °C, the hardness value of samples was significantly decreased. The relationship between ion irradiation induced microstructural evolution and the changes in the mechanical properties of this weld metal is discussed in the context of ion dose and irradiation temperature. [ABSTRACT FROM AUTHOR]