Generation of CTL responses against pancreatic cancer in vitro using dendritic cells co-transfected with MUC4 and survivin RNA.
- Resource Type
- Article
- Authors
- Chen, Jiang; Guo, Xiao-Zhong; Li, Hong-Yu; Liu, Xu; Ren, Li-Nan; Wang, Di; Zhao, Jia-Jun
- Source
- Vaccine. Sep2013, Vol. 31 Issue 41, p4585-4590. 6p.
- Subject
- *PANCREATIC cancer
*IN vitro studies
*CYTOTOXIC T cells
*DENDRITIC cells
*SURVIVIN (Protein)
*RNA
- Language
- ISSN
- 0264-410X
Highlights: [ • ] The CTL responses to pancreatic cancer induced by DCs in vitro. [•] DCs were loaded with 2 pancreatic tumor-associated antigens, MUC4 and survivin. [ • ] DC encoding 2 pancreatic TAA mRNAs induced a more potent CTL response toward PC. [•] The antigen-specific CTL response is restricted by MHC class I antigen presentation. [•] It is a prerequisite for DC vaccines encoding multiple pancreatic TAA epitopes. [ABSTRACT FROM AUTHOR]