The critical role of Sestrin 1 in regulating the proliferation of cardiac fibroblasts.
- Resource Type
- Article
- Authors
- Sun, Gang; Xue, Ruicong; Yao, Fengjuan; Liu, Dan; Huang, Huiling; Chen, Cong; Li, Yanhui; Zeng, Junyi; Zhang, Gaoxing; Dong, Yugang; Liu, Chen
- Source
- Archives of Biochemistry & Biophysics. Jan2014, Vol. 542, p1-6. 6p.
- Subject
- *CELL proliferation
*GENETIC regulation
*FIBROBLASTS
*SMALL interfering RNA
*COLLAGEN
*CONNECTIVE tissue growth factor
- Language
- ISSN
- 0003-9861
Highlights: [•] Downregulation of Sestrin 1 by siRNA promoted cardiac fibroblasts proliferation. [•] Downregulation of Sestrin 1 enhanced collagen type I and CTGF production. [•] Knockdown of Sestrin 1 induced fibroblasts proliferation related to increased ROS. [ABSTRACT FROM AUTHOR]