Polycystin-1 and polycystin-2--it's complicated.
- Resource Type
- Article
- Authors
- Watnick, Terry J.; Germino, Gregory G.
- Source
- Nature Reviews Nephrology. May2013, Vol. 9 Issue 5, p249-250. 2p.
- Subject
- *POLYCYSTINS
*CALCIUM channels
*GLYCOPROTEINS
*POLYCYSTIC kidney disease
*DEPHOSPHORYLATION
*PHOSPHORYLATION
- Language
- ISSN
- 1759-5061
The article discusses research on the complexities in the relationship between the autosomal dominant polycystic kidney disease (ADPKD) proteins polycystin-1 and polycystin-2. It references a study by A. J. Streets and colleagues published in an issue of "Human Molecular Genetics." A model of ADPKD pathogenesis that involves disruption of the balance between phosphorylation and dephosphorylation of polycystin-2 at Ser829 was suggested by the researchers.