Differential levels of resistance to disease induction and development of relapsing experimental autoimmune encelphalomyelitis in two H-2b-restricted mouse strains
- Resource Type
- Article
- Authors
- Li, Jinzhu; Zhao, Xiaoqing; Skoff, Robert; Shaw, Michael K.; Tse, Harley Y.
- Source
- Journal of Neuroimmunology. May2011, Vol. 234 Issue 1/2, p109-114. 6p.
- Subject
- *ENCEPHALOMYELITIS
*AUTOIMMUNE diseases
*DISEASE susceptibility
*LABORATORY mice
*MAJOR histocompatibility complex
*IMMUNOGLOBULINS
*IMMUNIZATION
- Language
- ISSN
- 0165-5728
Abstract: Besides the major histocompatibility complex (MHC) genes, background genes are believed to influence the encephalitogenicity of SJL(H-2s) and B10.S (H-2s) mice responding to myelin basic protein (MBP). A new mouse strain was constructed to study the effects of the SJL genetic background in mice responding to H-2b-restricted neuroantigens. Although the SJL.B (H-2b) mouse remained resistant to MBP in active EAE induction, the disease severity was uniformly higher in MOG-induced active EAE and in MBP-induced adoptive EAE when compared to those of B6 (H-2b) mice. Treatment of mice with anti-CD25 antibodies prior to immunization caused 60% of SJL.B mice to become susceptible to MBP-induced EAE while only 14% of B6 mice were converted. In addition, MOG-induced EAE in SJL.B mice followed a remitting–relapsing disease course while B6 mice only exhibited monophasic or chronic episodes. The new SJL.B mouse strain provides a valuable tool for studying EAE resistance and remitting–relapsing disease in H-2b mice. [Copyright &y& Elsevier]