Silylcarboxylic Acids as Bifunctional Reagents: Application in Palladium‐Catalyzed External‐CO‐Free Carbonylative Cross‐Coupling Reactions.
- Resource Type
- Article
- Authors
- Li, Xiong; Xu, Jie; Li, Yue; Kramer, Søren; Skrydstrup, Troels; Lian, Zhong
- Source
- Advanced Synthesis & Catalysis. 10/6/2020, Vol. 362 Issue 19, p4078-4083. 6p.
- Subject
- *ARYL iodides
*ACIDS
*DIALKYLZINC
*FUNCTIONAL groups
- Language
- ISSN
- 1615-4150
A palladium‐catalyzed external‐CO‐free carbonylative Hiyama‐Denmark cross‐coupling reaction is presented. The introduction of silylcarboxylic acids as bifunctional reagents (CO and nucleophile source) avoids the need for external gaseous CO and a silylarene coupling partner. The transformation features high functional group tolerance and it is successful with electron‐rich, ‐neutral, and ‐poor aryl iodides. Stoichiometric studies and control experiments provide insight into the reaction mechanism and support the hypothesized dual role of silylcarboxylic acids. [ABSTRACT FROM AUTHOR]