The biological and clinical significance of helper T-cell subsets in the human.
- Resource Type
- Article
- Authors
- Müller, Kai M.; Hauser, Conrad
- Source
- Experimental Dermatology. Nov92, Vol. 1 Issue 4, p161-169. 9p.
- Subject
- *T cells
*MAJOR histocompatibility complex
*CD4 antigen
*PEPTIDES
*INTERLEUKIN-2
*IMMUNITY
- Language
- ISSN
- 0906-6705
This article discusses the biological and clinical significance of helper T-cell subsets in humans. CD4[sup+] T cells are the principal regulatory cells of the immune system. They are commonly referred to as T-helper/inducer cells. CD4[sup+] T cells recognize antigen-derived peptides bound to major histocompatibility complex (MHC) class II molecules. Besides this central recognition event, however, additional molecular interactions are required for full T-cell activation, such as co-ligation of MHC class II molecules by CD4. Primary activated CD4[sup+] cells produce Interleukin-2 but little or no other Lk.