Probing Inhibitor-Induced Conformational Changes along the Interface between Tissue Factor and...
- Resource Type
- Article
- Authors
- Osterlund, Maria; Owenius, Rikard; Carlsson, Karin; Carlsson, Uno; Persson, Egon; Lindgren, Mikael; Freskgard, Per-Ola; Svensson, Magdalena
- Source
- Biochemistry. 8/7/2001, Vol. 40 Issue 31, p9324. 5p. 1 Diagram, 7 Graphs.
- Subject
- *PROTEIN conformation
*BINDING sites
*ENZYME inhibitors
*PROTEOLYTIC enzymes
- Language
- ISSN
- 0006-2960
Examines the inhibitor-induced conformational changes along the interface between tissue factor and activated factor VIIa. Comparison of the interactions of active site-inhibited factor VIIa and FVIIa with soluble TF (sTF); Impact of the inhibition of FVIIa on the structures around the positions in sTF that interact with the protease domain of FVIIa.