Inhibiting HIV-1 entry: Discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.
- Resource Type
- Article
- Authors
- Eckert, Debra M.; Malashkevich, Vladimir N.
- Source
- Cell. 10/01/99, Vol. 99 Issue 1, p103. 13p. 5 Diagrams, 3 Charts, 5 Graphs.
- Subject
- *PEPTIDES
*PEPTIDE drugs
*HIV
- Language
- ISSN
- 0092-8674
Identifies a pocket on the surface of a central trimeric coiled coil within gp41 as a potential target for drugs that inhibit HIV-1 entry. Classification of D-peptide inhibitors of HIV-1 infection; Use of IQN17 and mirror image phage display; Effect of IQN17 and D-peptide for the identification of the HIV-drugs.