Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine.
- Resource Type
- Article
- Authors
- Dolle, Martijn E.T.; Snyder, Wendy K.
- Source
- Proceedings of the National Academy of Sciences of the United States of America. 07/18/2000, Vol. 97 Issue 15, p8403. 6p. 1 Diagram, 1 Chart, 3 Graphs.
- Subject
- *GENETIC mutation
*MICE
*GENETICS
- Language
- ISSN
- 0027-8424
Presents the completely characterized mutational spectra, ranging from point mutations to large genomic rearrangements, in an actively proliferating and a postmitotic organ from young and old mice. Mutant characterization; Mutation accumulation in heart and small intestine; Molecular characterization of point mutations and size-change mutants.