The present studies were conducted to evaluate the impacts of sowing times, plant-to-plant distances, sowing methods and field sanitation on infestation of Bactrocera cucurbitae and yield of Momordica charantia. Evaluated cultural practices exhibited a significant effect on infestation of B. cucurbitae and yield of M. charantia. Early sowing (15 February), plant-to-plant distance 45 cm, Hang Sowing Method (HSM) and sanitation measure were better cultural practices as these cultural practices exhibited lower fruit-infestation and yield-losses/plant but higher marketable-fruits/plant and marketable-yield/plant. Early sowing with a plant-to-plant distance of 45 cm demonstrated 2-3 times less fruit-infestation and yield-losses/plant, whereas approximately 1-2 times increase in marketable-fruits and marketable-yield per plant compared to other interactions between sowing times and plant-to-plant distances. HSM demonstrated approximately 1.3 times less fruit-infestation and yield-losses/plant, whereas 1.5 times more marketable-fruits and marketable-yield per plant compared to FSM. Similarly, sanitation measures exhibited 1.7 and 1.4 times reduction in the fruit-infestation and yield-loss/plant, respectively; but 2.4 and 3.2 times increase in marketable-fruits/plant and marketable-yield/plant, respectively over no sanitary measures. In conclusion, early sowing (15 February) with plant-to-plant distance of 45 cm, HSM and sanitation practice can be recommended for integration with other IPM practices against melon fruit fly in cucurbit cropping system. © 2014 Friends Science Publishers [ABSTRACT FROM AUTHOR]