13C Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeaeElectronic supplementary information (ESI) available: Details of culture condition of D. zeae, isolation and spectroscopic data for zeamine 8. See DOI: 10.1039/b916307g
- Resource Type
- Article
- Authors
- Wu, Jien; Zhang, Hai-Bao; Xu, Jin-Ling; Cox, Russell J.; Simpson, Thomas J.; Zhang, Lian-Hui
- Source
- Chemical Communications. 1/14/2010, Vol. 46 Issue 2, p333-335. 3p.
- Subject
- *ANTIBIOTIC synthesis
*RADIOLABELING
*CARBON isotopes
*AMINATION
*POLYKETIDES
*POLYAMINES
*AMINOTRANSFERASES
*NUCLEAR magnetic resonance
- Language
- ISSN
- 1359-7345
The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeaehas been established by NMR and detailed MS analyses; labelling studies with 13C-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised viaa modular PKS containing aminotransferase domains. [ABSTRACT FROM AUTHOR]