Topographical study of O 6-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue.
- Resource Type
- Article
- Authors
- Crosbie, Philip A.J.; Harrison, Kathryn; Shah, Rajesh; Watson, Amanda J.; Agius, Raymond; Barber, Philip V.; Margison, Geoffrey P.; Povey, Andrew C.
- Source
- Chemico-Biological Interactions. Jul2013, Vol. 204 Issue 2, p98-104. 7p.
- Subject
- *GUANINE
*DNA repair
*TRANSFERASES
*O6-Methylguanine-DNA Methyltransferase
*LUNG physiology
*ALKYLATING agents
- Language
- ISSN
- 0009-2797
Highlights: [•] Geographical variation in susceptibility to alkylating agents in lung investigated. [•] MGMT repair increased towards the lung periphery. [•] Smoking may reduce MGMT repair in central but not peripheral lung tissue. [•] Alkylating agent exposure (N7-meG levels) not related to lung position. [•] No evidence peripheral lung more susceptible to genotoxic alkylating agents. [Copyright &y& Elsevier]