The article examines the risk factors for laboratory confirmed sexually transmitted disease (STD) prevalence among low-income African American adolescent females living in a high-risk urban area in the southern part of the U.S. As part of the experimental design, 715 African American adolescent females were recruited from urban clinics as the subjects of the study. Furthermore, data collection occurred from 2002-2004 and included an audio-computer assisted self-interview lasting about 60 minutes. Based on the results, 28.8% of the participants tested were positive for at least one STD and adolescents' who had higher levels of fear pertaining to condom use negotiation were more likely to test positive as were adolescents who perceived higher levels of social support from their peers.