This article is devoted to the problem of organizing geo-ecological monitoring of water supply for territories with conditions of active karst processes. In these cases, the task is complicated by the difficult hydrogeological conditions of the locality and the high vulnerability of karst groundwater resources to pollution due to their complex hydrogeological structure. Karst water exchange systems are characterized by high natural and anthropogenic vulnerability of groundwater resources, and their extremely low ability to self-purification and dispersion of pollutants. It should also be noted the serious negative impact of water use conditions on the facilities and safety of agro-industrial complex products in such territories. As a result of karst development in these territories, water exchange is intensified and its structure is radically changed, and the resulting huge spatial heterogeneity of reservoir and filtration properties leads to a multicomponent filtration environment and the complexity of geo-ecological assessment of water use conditions in this territory. The solution to this scientific problem should be based on the development of concepts, methods and algorithms for assessing and predicting environmental risk based on the processing and analysis of large volumes of heterogeneous data of complex geo – ecological monitoring of local, local and regional levels using GIS technologies. This work substantiates the use of new methods of extraction the karst-dangerous key areas, providing a detailed level of information-analytical typing and evaluation of conditions of natural-technogenic environment of karst territories to anticipate changes in the geoecological situation of water use. [ABSTRACT FROM AUTHOR]