We show that relativistic causality is violated in the early stages of state-of-the-art heavy-ion hydrodynamic simulations of nuclear collisions. Up to 75% of the initial fluid cells violate nonlinear causality constraints, while superluminal propagation is observed by up to 15% the speed of light. Only after 2-3 fm/c of evolution, do 50% of the fluid cells become definitely causal. Inclusion of pre-equilibrium evolution significantly reduces the number of acausal cells, but it does not eliminate them. Relativistic causality thus imposes constraints on the model parameter space of heavy-ion collision simulations. [ABSTRACT FROM AUTHOR]