Stereoselective Synthesis of Erythronolide A via Nitrile Oxide Cycloadditions and Related Studies.
- Resource Type
- Article
- Authors
- Muri, Dieter; Carreira, Erick M.
- Source
- Journal of Organic Chemistry. 11/20/2009, Vol. 74 Issue 22, p8695-8712. 18p.
- Subject
- Language
- ISSN
- 0022-3263
An expeditious synthesis of erythronolide A is documented. Key steps of the approach include two magnesium-mediated nitrile oxide cycloadditions, a chelation-controlled Grignard reaction, and a Sharpless asymmetric dihydroxylation. [ABSTRACT FROM AUTHOR]