Vitamin D metabolism and innate immunity
- Resource Type
- Article
- Authors
- Lagishetty, Venu; Liu, Nancy Q.; Hewison, Martin
- Source
- Molecular & Cellular Endocrinology. Dec2011, Vol. 347 Issue 1/2, p97-105. 9p.
- Subject
- *VITAMIN D
*METABOLISM
*NATURAL immunity
*CHRONIC granulomatous disease
*IMMUNE system
*IMMUNOREGULATION
*MONOCYTES
*ENZYMES
- Language
- ISSN
- 0303-7207
Abstract: Effects of vitamin D on the immune system have been recognized for over 30years and stemmed in part from analysis of the dysregulated vitamin D metabolism associated with granulomatous diseases. However, it is only in more recent years that a role for interaction between vitamin D and normal immune function has been proposed. As with the original studies, the basis for this new perspective on immunomodulation by vitamin D stems from studies of vitamin D metabolism by immune cells. In particular, induction of the vitamin D-activating enzyme CYP27B1 in monocytes via pathogen recognizing receptors has highlighted an entirely new function for vitamin D as a potent inducer of antibacterial innate immune responses. This has prompted a new potential role for vitamin D in protecting against infection in a wide range of tissues but has also prompted revision of the parameters for adequate vitamin D status. The following review describes some of the key developments in innate immune responses to vitamin D with particular emphasis on the role of key metabolic enzyme as determinants of localized immune activity of vitamin D. [Copyright &y& Elsevier]