Identification of anti-allergic effect of Clonorchis sinensis-derived protein venom allergen-like proteins (CsVAL).
- Resource Type
- Article
- Authors
- Jeong, Young-Il; Kim, Yu-Jung; Ju, Jung-Won; Hong, Sung-Hee; Lee, Myoung-Ro; Cho, Shin-Hyeong; Lee, Won-Ja; Lee, Sang-Eun
- Source
- Biochemical & Biophysical Research Communications. Mar2014, Vol. 445 Issue 3, p549-555. 7p.
- Subject
- *ANTIALLERGIC agents
*CLONORCHIS sinensis
*MAST cells
*CELLULAR signal transduction
*REACTIVE oxygen species
*ALLERGIES
- Language
- ISSN
- 0006-291X
Highlights: [•] C. sinensis-derived CsVAL peptide inhibits the degranulation of mast cells. [•] CsVAL peptide inhibits FcεRI-mediated signal transduction in antigen-stimulated mast cell. [•] CsVAL peptide prevents ROS generation in antigen-stimulated mast cells. [•] CsVAL peptide inhibits the chronic contact hypersensitivity response. [ABSTRACT FROM AUTHOR]