(C) Kaplan-Meier curves for time to castration resistance in patients with germline BRCA2 alteration and germline BRCA2 wild-type gl Additionally, concurrent I HSD3B1 i genotype was detected in 348 (71.0%) of the 490 studied patients. (B) Kaplan-Meier curves for time to castration resistance in patients with germline DDR alteration and germline DDR wild-type. Germline deleterious alterations interrupting the function of DNA damage repair (DDR) have proven to be related to a high risk of prostate cancer (PCa), which are recommended for testing in general practice.1 Moreover, the genetic background has recently emerged as a potential factor in racial diversity, especially in the epidemiology of PCa.2 Since our understanding of the genomics was mostly derived from the Caucasian population, we conducted a real-world multicenter retrospective study of 490 patients with PCa across distinct clinical states in order to better elucidate the prevalence and clinical implication of rare germline deleterious alterations in Chinese men. [Extracted from the article]