Failure to reach therapeutic levels of rifampicin and isoniazid by recommended dosages.
- Resource Type
- Article
- Authors
- Chawla, Prerna K.; Lokhande, Rohan V.; Naik, Prasad R.; Dherai, Alpa J.; Amale, Rohit A.; Udwadia, Zarir F.; Mahashur, Ashok A.; Soman, Rajeev; Ashavaid, Tester F.
- Source
- Infectious Diseases. Jul2017, Vol. 49 Issue 7, p552-555. 4p. 2 Graphs.
- Subject
- *DRUG therapy for tuberculosis
*DRUG resistance in microorganisms
*MOLECULAR diagnosis
- Language
- ISSN
- 2374-4235
The article discusses a study related to therapeutic drug monitoring (TDM) of isoniazid and rifampicin in Indian patients suffering from active tuberculosis and on first-line treatment regimen. Topics discussed include no statistical significance of confounding factors such as age and body mass index with plasma rifampicin or isoniazid levels, majority of the patients showed sub-therapeutic rifampicin levels and malabsorption or delayed rifampicin in 2-h plasma peak levels.