Autopsies were performed in a specific COVID-19 designated autopsy room with airflow control and airborne infection control procedures including use of appropriated PPE (i.e., NIOSH-certified disposable N-95 respirator). Human herpesvirus 6 (HHV-6), a T-cell lymphotropic virus, is the sixth recognized member belonging to the Herpesviridae family and has been identified as the etiologic agent of exanthem subitum (Zahorsky's disease, sixth disease, and roseola infantum), a common childhood disease.1 HHV-6 infection can reactivate in immunocompromised or in immunocompetent adults and may cause encephalitis, interstitial pneumonia, and myocarditis with a high mortality rate, especially in fragile patients, although these effects occurred less frequently in immunocompetent hosts.2 Fulminant myocarditis is an acute inflammation of the myocardium that could manifest itself with unspecific symptoms like fatigue and shortness of breath or chest discomfort. Whole body post-mortem examination was performed according to guidance for post-mortem and collection and submission of specimens and biosafety practices, to reduce the risk of transmission of infectious pathogens during and after the post-mortem examination. [Extracted from the article]