In current study, a flow boiling experimental examination has been performed on water, water-TiO2 nanofluid, and water-Al2O3 nanofluid and Gradient Boost Regression model was established to predict the Nusselt number of TiO2 and Al2O3 nanofluids. Nusselt number was calculated by varying heat flux, Reynolds number, and volumetric concentration. Good agreement was shown by water results acquired from experiments with the correlation of Chen and CFD. Results demonstrated that the Nusselt number of TiO2 and Al2O3 nanofluid was larger than water. Increment in Nusselt number was noticed with the increment in concentration, heat flux, and Reynolds number. It was seen that Al2O3 nanofluid was superior to TiO2 nanofluid. Highest improvement in the Nusselt number was 37% shown by Al2O3 nanofluid when compared to water. Correlations of Nusselt number were developed for both nanofluids. GBR-GSO machine learning model showed a good agreement with the experimental Nusselt number. [ABSTRACT FROM AUTHOR]