In the first of many thematic issues marking the 30th anniversary of Cell Chemical Biology , we highlight the contribution of chemical biology to RNA biology in a special issue on RNA modulation. We asked several leaders in the field to share their opinions on the current challenges and opportunities in RNA biology. [Display omitted] In the first of many thematic issues marking the 30th anniversary of Cell Chemical Biology , we highlight the contribution of chemical biology to RNA biology in a Special Issue on RNA Modulation. We asked several leaders in the field to share their opinion on the current challenges and opportunities in RNA biology. [ABSTRACT FROM AUTHOR]