However, contrary to Mendias and Bedi we do believe sFLCs were a useful marker of inflammation to study in the FAI population. In common with all biomarkers sFLCs have a lower limit of clinical sensitivity, so normal levels of sFLCs cannot exclude the possibility of low levels of inflammation; however, the inflammatory response would have to be minimal to be undetectable. With time it is likely that sFLC measurements will have more general applications in the detection of inflammation, particularly in the context of impaired liver, renal, and cardiovascular function.[9]. [Extracted from the article]