Background: Limited data on immune checkpoint inhibitor (ICI)‐induced pruritus per se and efficacy of different therapeutic modalities in its management exist. Objective: To study the quantitative and qualitative characteristics of ICI‐induced pruritus per se and to assess the efficacy of the therapeutic modalities usually applied. Methods: We retrospectively reviewed the records of 91 patients who were under treatment with ICIs for any kind of neoplasia and developed pruritus during treatment. Results: Twenty out of 91 individuals (22.0%) with ICI‐induced pruritus had pruritus as the only symptom, while 71/91 (78.0%) presented with pruritus coexisting with an additional cutaneous toxicity. Pruritus was treated with antihistamines (18/20, 90.0%) and/or topical regimens, as first‐line choice. In resistant cases, as a second therapeutic intervention, narrow‐band UVB (NBUVB), oral steroids and GABA analogs were added (70.0%). Statistical analysis revealed a significant difference in mean pruritus Numerical Rating Scale (NRS) scores between baseline and sequential visits. Moreover, subgroup analysis revealed a significant reduction in mean NRS scores in those treated with phototherapy. Limitations: Retrospective design, low number of patients and survivorship bias. Conclusion: Pruritus per se was present in a substantial portion of our cohort (22.0%). Our study confirms the efficacy of current treatment strategies and suggests NBUVB as a potential steroid‐sparing therapeutic alternative. [ABSTRACT FROM AUTHOR]