The level of detection was highest when platelets were gated using the CD42b marker, suggesting a competition between patient autoantibodies and CD41/CD61, which stain for integrin SB IIb sb SB 3 sb . To investigate whether the patient had anti-platelet autoantibodies, we isolated platelets from healthy controls ( I n i = 8) as previously described[14] and incubated these with either control or patient plasma, in the presence/absence of platelet inhibitors (apyrase and prostaglandin E1) or collagen. Flow cytometry results clearly indicated that the patient presented both IgG and IgA against platelets. Glanzmann's thrombasthenia (GT) is a rare haemostatic disorder characterised by an impaired function of integrin SB IIb sb SB 3 sb . [Extracted from the article]