Footnotes 1 Nonstandard Abbreviations and Acronyms I/R ischemia/reperfusion KO knockout SGLT2 sodium glucose cotransporter-2 SGLT2i sodium glucose cotransporter-2 inhibitor WT wild-type 2 S. Chen, Q. Wang, and A. Christodoulou contributed equally. Keywords: body weight; empagliflozin; glucose; infarct size; ischemia/reperfusion; ketones; sodium-glucose cotransporter 2 inhibitor EN body weight empagliflozin glucose infarct size ischemia/reperfusion ketones sodium-glucose cotransporter 2 inhibitor 276 279 4 01/17/23 20230117 NES 230117 Empagliflozin, a sodium glucose cotransporter-2 (SGLT2) inhibitor (SGLT2i), developed to facilitate glycosuria in patients with diabetes, has a large beneficial effect in patients with heart failure. [Extracted from the article]