The patient subsequently developed genital ulcers, and met clinical criteria for Behçet's syndrome (recurrent oral aphthous ulcers, genital ulceration, skin features). B Cutaneous ulcerations demonstrating pathergy (left), periungual lesion (middle), and an ulcerative scalp lesion (right) C-D Immunophenotyping of patient cells demonstrated C increased frequency of CD4-CD8- TCR + T cells (gated on CD3 + TCR / + cells). 1Clinical features of patient with Behçet's syndrome and STAT1 functional testing. In the largest published cohort of STAT1 GOF patients (247 patients), 98% had CMC [[1]], however other clinical symptoms can vary, even with the same variant. [Extracted from the article]