Highly Stereoselective Synthesis of FunctionalizedPyrrolo[3,2-c]quinolines via N-Heterocyclic Carbene Catalyzed Cascade Sequence.
- Resource Type
- Article
- Authors
- Yang, Yu-Jie; Zhang, Hai-Rui; Zhu, Shi-Ya; Zhu, Ping; Hui, Xin-Ping
- Source
- Organic Letters. Oct2014, Vol. 16 Issue 19, p5048-5051. 4p.
- Subject
- *QUINOLINE
*CHEMICAL synthesis
*HETEROCYCLIC compounds
*MANNICH reaction
*STEREOSELECTIVE reactions
*ALDIMINES
- Language
- ISSN
- 1523-7060
An N-heterocycliccarbene-catalyzed stereoselectiveMichaelâMannichâlactamization cascade reaction of tosyl-protected o-amino aromatic aldimines and 2-bromoenals for the constructionof functionalized pyrrolo[3,2-c]quinolines with threeconsecutive stereocenters was achieved in good yields with excellentdiastereo- and enantioselectivities. [ABSTRACT FROM AUTHOR]