Palladium‐Catalyzed Sequential C−H Activation/Amination of 2‐Iodobiphenyls with Benzoisoxazoles for Synthesis of Carbazoles.
- Resource Type
- Article
- Authors
- Zhao, Ya‐Heng; Chen, Jun‐Hua; Liu, Miao‐Chang; Zhou, Yun‐Bing; Wu, Hua‐Yue
- Source
- Advanced Synthesis & Catalysis. 9/6/2022, Vol. 364 Issue 17, p2939-2943. 5p.
- Subject
- *KETONES
*AMINATION
*ALDEHYDES
*OXIDIZING agents
*CATALYSIS
*EMPLOYMENT
- Language
- ISSN
- 1615-4150
A coupling reaction of 2‐iodobiphenyl with benzoisoxazole under the cooperative catalysis of Pd(CH3CN)2Cl2 and P(4‐F−Ph)3 is disclosed. The reaction proceeds via intramolecular C−H activation/N−O cleavage/migratory insertion sequence to give an array of N‐arylcarbazoles with an aldehyde or a ketone. The employment of benzoisoxazoles as an amination agent obviates the need for stoichiometric amount of oxidants. [ABSTRACT FROM AUTHOR]