The synthesis of quaternized glucosamide-based trisiloxane surfactant (QGS) of the general formula MeSiOSiMeROSiMe (R = (CH)N(CH)(CH)R, R = glucosamide group) was described, and the surface activity properties of the surfactant were studied. The N-[2-(dimethylamino)ethyl]- d-gluconamide was synthesized by amidation of the ethylenediamine with d-gluconolactone. The 3-(3-chloropropyl)-1,1,1,3,5,5,5-heptamethyltrisiloxane was prepared by the acid-catalyzed reaction of a silane monomer. The QGS was prepared by quaternization of the precursor halogenated hydrocarbon with a tertiary amine. They were structurally characterized by IR, H NMR and MS. And it reduced the surface tension of water to approximately 21 mN m at concentration levels of 10 mol L. [ABSTRACT FROM AUTHOR]