A combination strategy using two novel cerium-based nanocomposite affinity probes for the selective enrichment of mono- and multi-phosphopeptides in mass spectrometric analysis.
- Resource Type
- Article
- Authors
- Long, Xing-yu; Zhang, Zi-jin; Li, Jia-yuan; Sheng, Dong; Lian, Hong-zhen
- Source
- Chemical Communications. 4/28/2017, Vol. 53 Issue 33, p4620-4623. 4p.
- Subject
- *CERIUM
*NANOCOMPOSITE materials
- Language
- ISSN
- 1359-7345
This work presents a sequential enrichment protocol, based on two self-designed cerium-based nanocomposite affinity probes, which not only can effectively separate phosphopeptides from non-phosphopeptides but can also selectively differentiate mono- and multi-phosphopeptides for direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF MS) analysis. [ABSTRACT FROM AUTHOR]