In this work, novel MXenes/MoS2 heterojunction of flower-like MoS2 decorated sheet-like MXenes were successfully fabricated by one-step hydrothermal approach using TiO2 as the precursor, and systematically investigated by a series of characterizations (e.g. XRD, Raman, SEM, and TEM analysis). Furthermore, the tribological behaviour of MXenes/MoS2 heterojunction in liquid paraffin were extensively examined a ball-on-disk tribometer. The effects of applied load and rotational speed were also investigated. The experimental results indicated the friction and wear was significant decreased with introduction of MXenes/MoS2 heterojunction. Especially, 5%-MXenes/MoS2-paraffin samples show the lowest friction coefficient (~0.10). Additionally, the construction and excellent tribological properties of MXenes/MoS2 heterojunction would be beneficial for the design of novel nano-additives with 2D/2D structure for enhancing friction reduction and anti-wear, which also would expand their actual applications in the industry and agriculture. [ABSTRACT FROM AUTHOR]