Phloroglucinol derivatives with α-glucosidase inhibitory activities from Syzygium fluviatile.
- Resource Type
- Article
- Authors
- Zhang, Ding-Li; Hu, Yi-Kao; Wang, Li; He, Yuan-Biao; Yang, Jing; Zhao, Yong
- Source
- Journal of Asian Natural Products Research. Dec2023, Vol. 25 Issue 12, p1168-1174. 7p.
- Subject
- *FOLIAR diagnosis
*EXPERIMENTAL design
*HIGH performance liquid chromatography
*HYPOGLYCEMIC agents
*NUCLEAR magnetic resonance spectroscopy
*TYPE 2 diabetes
*GLYCOSIDASES
*DESCRIPTIVE statistics
*RESEARCH funding
*PLANT extracts
*MOLECULAR structure
*THIN layer chromatography
*PHARMACODYNAMICS
*CHEMICAL inhibitors
- Language
- ISSN
- 1028-6020
Four new phloroglucinol derivatives (1 − 4) were isolated from the leaves of Syzygium fluviatile. Their structures were elucidated by means of extensive spectroscopic data. Among them, compounds 1 and 3 showed significant inhibitory activity against α-glucosidase with IC50 values of 10.60 and 5.07 µM, respectively. The structure-activity relationship was also discussed briefly. [ABSTRACT FROM AUTHOR]