A new medermycin analog from the marine-derived actinomycetes Streptomyces sp. ZS-A45.
- Resource Type
- Article
- Authors
- Huang, Yun; Jiang, Qing; Chen, Yu-Hong; Zhang, Da-Shan; Ding, Wan-Jing; Ma, Zhong-Jun
- Source
- Journal of Asian Natural Products Research. Aug2019, Vol. 21 Issue 8, p826-831. 6p.
- Subject
- *CELL lines
*CHROMATOGRAPHIC analysis
*STATISTICAL correlation
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*SPECTROPHOTOMETRY
*ACTINOBACTERIA
- Language
- ISSN
- 1028-6020
A new medermycin analog (1) was isolated from the marine-derived actinomycetes Streptomyces sp. ZS-A45. The structure elucidation of compound 1 was determined by the HRESIMS and extensive NMR analysis. And compound 1 exhibited significant cytotoxicity against PC3 cell lines with IC50 values of 0.81 ± 0.42 μm. [ABSTRACT FROM AUTHOR]