Single‐cell RNA‐seq reveals the links between the metabolic heterogeneity and cell identity in NBM and AML.
- Resource Type
- Article
- Authors
- Lu, Qiongyu; Qu, Wenqiang; Wen, Yuxin; Ke, Peng; Zhao, Luyao; Wang, Qingyuan; Chen, Suning; Zeng, Zhao
- Source
- British Journal of Haematology. Mar2024, Vol. 204 Issue 3, p1100-1104. 5p.
- Subject
- *ACUTE myeloid leukemia
*METABOLOMICS
*RNA sequencing
*HETEROGENEITY
*HEMATOPOIETIC stem cells
*CYTOTOXIC T cells
- Language
- ISSN
- 0007-1048
This article explores the metabolic heterogeneity of acute myeloid leukemia (AML) at the single-cell level. The study reveals that AML cells exhibit distinct metabolic features and that metabolic heterogeneity is correlated with cell differentiation and certain genetic alterations. The researchers also found that primitive cell types in both normal bone marrow and AML display higher metabolic heterogeneity. The findings highlight the importance of understanding metabolic heterogeneity for identifying drug-resistant subtypes of cells and improving therapeutic interventions for AML. [Extracted from the article]