Chiral Betaine-Mediated Efficient Organocatalytic Asymmetric Isomerization of β,γ-Unsaturated Butenolides.
- Resource Type
- Article
- Authors
- Zeng, Yiqun; Fei, Chao; Zhou, Xiao; Luo, Jisheng; Deng, Li
- Source
- Synlett. Dec2023, Vol. 34 Issue 20, p2429-2432. 4p.
- Subject
- *BETAINE
*BUTENOLIDES
*ISOMERIZATION
*CINCHONA alkaloids
*RESEARCH personnel
- Language
- ISSN
- 0936-5214
This article discusses a study on the development of a new catalyst for the asymmetric isomerization of β,γ-unsaturated butenolides. The researchers found that chiral betaines derived from precursors were highly efficient catalysts for this reaction. They optimized the reaction conditions and successfully synthesized a range of chiral α,β-butenolides with high enantioselectivity. This research has potential applications in the synthesis of biologically active molecules. The study provides a detailed description of the catalytic cycle and suggests that chiral betaines could be used in various catalytic asymmetric reactions. The supporting information for the study is available online. [Extracted from the article]