Background: Previous studies presented that ascorbic acid (AA) plays an important role in atherosclerosis conditions. Also, it neutralizes the Reactive Oxygen Species (ROS) in endothelium by reducing inflammatory biomarkers. This systematic review aims to evaluate the association between AA and vascular adhesion molecules (VCAM-1), intracellular adhesion molecules (ICAM-1), neutrophil recruitment and tumor necrosis factor-alpha (TNF-a). Methods: A systematic search was performed on databases including Cochrane, Pubmed, Scopus, and Google Scholar from inception to 25 of December 2021. After performing screening among seven hundred twenty-five studies, 33 articles were included for reading the full text. Finally, fifteen articles were included for this study. Just two intervention study data extract for ICAM-1 plasma level in diabetic and claudicate patients. Results: We found that the AA attenuates ox-LDL in cardiovascular diseases. Also, the plasma concentration of AA and ICAM-1 and VCAM-1 are contrariwise. Thus intravenous infusion of vitamin C in two intervention studies in dosages of 1000 up to 3000 mg reduces the plasma ICAM-1 concentration SMD (-7.46 95% confidence interval (-12.83, -2.08)in, p-value<0.006. Therefore, vitamin C protects endothelial walls agonist TNF-a apotheosis. The AA in long term improves certain echocardiographic parameters. Moreover, low AA status induces endothelial dysfunction in obese men. Conclusion: There is an inverse relationship between AA plasma concentration and ICAM-1, VCAM-1 and TNF-a. Also, low AA status activates endothelial dysfunctions. [ABSTRACT FROM AUTHOR]