The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia.
- Resource Type
- Article
- Authors
- Behjat Sasan, Sanam; Zandvakili, Farnaz; Soufizadeh, Nasrin; Baybordi, Elaheh
- Source
- Obstetrics & Gynecology International. 8/17/2017, p1-5. 5p.
- Subject
- *PREECLAMPSIA
*VITAMIN D deficiency
*DIETARY supplements
*PREGNANCY complications
*CLINICAL trials
- Language
- ISSN
- 1687-9589
Introduction. Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials. The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks. The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. Results. The patients in intervention group have significantly lower (P value = 0.036) probability of preeclampsia than patients in the control group. The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71). Conclusion. The intended intervention (i.e., prescription of vitamin D) has a protective effect against recurrent preeclampsia. Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia. Registration. This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1. [ABSTRACT FROM AUTHOR]