(R, E)-7-((tert -Butyldimethylsilyl)oxy)-6-methylhept-4-enoic Acid (35) Compound B 34 b (3.6 g, 12.0 mmol) was dissolved in a mixed solution of THF/water (4:1; 38 mL), then anhydrous lithium hydroxide (0.58 g, 24.2 mmol) was added and the mixture was heated to 50 °C and stirred for 3 hours. (3 R,7 S,8 S,11 R,12 S,13 R,14 R, E)-12-((tert -Butyldimethylsilyl)oxy)-14-methoxy-16-... Acid B 2 b (0.67 g, 3.90 mmol) was dissolved in anhydrous DCM (28 mL), and DMAP (1.05 g, 8.6 mmol) and EDCI (0.66 g, 3.44 mmol) were added, followed by dropwise addition of alcohol B 3 b (1.04 g, 1.72 mmol, dissolved in 4 mL of DCM). (S)-4-Benzyl-3-((R, E)-7-((tert -butyldimethylsilyl)oxy)-6-methylhept-4-enoyl)oxazolidin-2-o... Compound B 35 b (3.1 g, 11.4 mmol) was dissolved in anhydrous THF (64 mL), the mixture was cooled to -10 °C and triethylamine (4.23 mL, 30.4 mmol) was added, followed by pivaloyl chloride (1.57 g mL, 12.5 mmol). (2 R,3 S,6 R,7 S,8 R,9 R, E)-7-((tert -Butyldimethylsilyl)oxy)-3-hydroxy-9-methoxy-11-(... Diol B 43 b (300 mg, 0.48 mmol), amine B 45 b (11 mg, 0.05 mmol), and DIPEA (0.14 mL, 0.8 mmol) were dissolved in anhydrous CH SB 3 sb CN (14 mL), then I p i -toluenesulfonyl chloride (136 mg, 0.71 mmol) was added and the mixture was stirred at room temperature for 24 hours. [Extracted from the article]