Engineering DNA-based synthetic condensates with programmable material properties, compositions, and functionalities.
- Resource Type
- Article
- Authors
- Sungho Do; Lee, Chanseok; Taehyun Lee; Do-Nyun Kim; Yongdae Shin
- Source
- Science Advances. 10/14/2022, Vol. 8 Issue 41, p1-14. 14p.
- Subject
- *PALINDROMIC DNA
*SINGLE-stranded DNA
*DNA structure
*PHASE transitions
*FLUORESCENCE yield
- Language
- ISSN
- 2375-2548
The article presents a study which showed that the synthetic condensates can accelerate DNA strand displacement reactions and logic gate operation by concentrating specific reaction components. Topics include control of condensation and dissolution of the DNA condensates, characteristics of the kinetics and thermodynamics of the selective partitioning of client strands into specific condensates, and composition control of the DNA condensates.