Background: The heterogeneity of childhood atopic dermatitis (AD) underscores the need to understand latent phenotypes that may inform risk stratification and disease prognostication. Objective: To identify AD trajectories across the first 8 years of life and investigate risk factors associated with each trajectory and their relationships with other comorbidities. Methods: Data were collected prospectively from 1152 mother‐offspring dyads in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort from ages 3 months to 8 years. AD was defined based on parent‐reported doctor's diagnosis. An unsupervised machine learning technique was used to determine AD trajectories. Results: Three AD trajectories were identified as follows: early‐onset transient (6.3%), late‐onset persistent (6.3%) and early‐onset persistent (2.1%), alongside a no AD/reference group (85.2%). Early‐onset transient AD was positively associated with male gender, family history of atopy, house dust mite sensitization and some measures of wheezing. Early‐onset persistent AD was associated with antenatal/intrapartum antibiotic use, food sensitization and some measures of wheezing. Late‐onset persistent AD was associated with a family history of atopy, some measures of house dust mite sensitization and some measures of allergic rhinitis and wheezing. Conclusion and Clinical Relevance: Three AD trajectories were identified in this birth cohort, with different risk factors and prognostic implications. Further work is needed to understand the molecular and immunological origins of these phenotypes. [ABSTRACT FROM AUTHOR]