Brain Region-Specific Mechanisms for Acute Morphine-Induced Mitogen-activated Protein Kinase Modulation and Distinct Patterns of Activation during Analgesic Tolerance and Locomotor Sensitization.
- Resource Type
- Article
- Authors
- Eitan, Shoshana; Bryant, Camron D.; Saliminejad, Nazli; Yang, Yu C.; Vojdani, Elroy; Keith Jr., Duane; Polakiewicz, Roberto; Evans, Christopher J.
- Source
- Journal of Neuroscience. 9/10/2003, Vol. 23 Issue 23, p8360. 10p. 2 Color Photographs, 2 Black and White Photographs, 5 Graphs.
- Subject
- *MORPHINE
*NARCOTICS
*MITOGENS
*PROTEIN kinases
*BRAIN
*MICE
*IMMUNOGLOBULINS
- Language
- ISSN
- 0270-6474
Presents information on a study which examined morphine-induced mitogen-activated protein kinase (MAPK) modulation in the mouse brain using antibodies against phosphorylated MAPK. Types of synaptic plasticity that require MAPK activation; Materials and methods; Results; Activation of the MAPK after acute systemic morphine administration in many cortical areas and the locus ceruleus.